RESEARCH: Baculoviruses are a group of occluded insect viruses that have
received considerable attention because of their potential for
application in insect control programs and their widespread use as
expression vectors. They encode a unique RNA polymerase that expresses
several late genes at some of the highest levels reported for
eukaryotic systems. My research is currently focused on two main
areas. These include the characterization the roles of viral and host
gene products in viral replication. Most recently this has led to
investigations on insect p53 and a viral sulfhydryl oxidase that
interacts with p53. In addition, the role that the host DNA damage
response plays in viral replication is being examined. The other area
of research involves the characterization of a group of insect
retroviruses that appear to have an evolutionary relationship with
baculoviruses. This is based on the observation that the envelope
protein of a major lineage of baculoviruses is related the env protein
from a lineage of insect retroviruses called errantiviruses.